•               Iatrogenic
ₒ              Glucocorticoid or mineralocorticoid treatment
ₒ              ACTH treatment
ₒ              Pituitary
•              Pituitary tumors
•              Adrenal tumors
ₒ              Carcinoma
ₒ              Adenoma
•              Adrenal nodular hyperplasia
ₒ              Carney complex (AD) (gene PRKAR1A; OMIM 160980)
ₒ              McCune-Albright syndrome (gene GNAS1; OMIM 174800)
•              Ectopic ACTH-producing tumors
•             Apparent mineralocorticoid excess (gene HSD11B2; OMIM 218030)
•              Glucocorticoid remediable hyperaldosteronism (AD) (gene chimeric CYP11B1/B2; OMIM 103900)

Table 3: Causes of adrenal cortical hyperfunction.