Trait

Ch1

Ch2

Loc1

Loc2

LOD

aa

ad

da

dd

%
       

MALES

        

 

TOID (5.768, 4.474)

41.3

TOID

1

10

21

31

4.49

  

*

*

*

 

TOID

1

11

33

42

4.85

*

    

*

 

TOID

2

11

18

72

4.51

*

*

*

  

 

TOID

4

11

9

40

4.58

*

*

*

*

 

TOID

4

15

72

10

4.50

  

*

*

*

 

TOID

4

17

72

19

5.85

  

*

*

*

 

TOID

8

9

19

56

4.64

*

*

    

 

TOID

9

13

54

33

5.16

  

*

*

*

 

TOID

10

11

31

44

4.59

*

  

*

*

 

TA (5.855,4.881)

 
       

FEMALES

        

 

TOID (5.719, 4.986)

17.0

TOID

1

7

67

44

5.29

      

*

 

TOID

10

17

66

46

5.07

*

  

*

*

 

TA (5.307, 4.319)

32.2

TA

1

19

54

51

4.38

*

*

    

 

TA

2

14

72

56

4.75

*

*

  

*

 

TA

3

12

74

7

4.57

*

  

*

*

 

TA

12

13

7

22

4.54

*

*

    

 

TA

14

17

35

37

4.51

    

*

*

 

TI (5.056, 4.220)

15.2

TI

2

4

91

70

4.50

*

*

    

 

TTW (5.133, 4.050)

32.1

TTW

3

12

74

7

4.60

*

  

*

*

 

TTW

5

11

79

5

4.29

      

*

 

TTW

12

13

7

21

4.55

*

*

    

 

TTW

14

17

35

37

4.09

    

*

*

 

MET (6.081, 4.962)

28.7

MET

10

19

5

3

5.49

*

    

*

 

MET

11

19

16

9

4.97

    

*

*

 

AMN (5.202, 4.429)

26.2

AMN

1

3

36

46

5.35

*

*

    

 

AMN

1

7

47

16

4.89

      

*

 

AMN

1

8

47

12

4.47

*

      

 

AMD (5.542, 4.511)

24.0

AMD

1

3

56

46

5.14

*

*

    

 

AMD

1

7

50

47

4.91

      

*

 
Table 1: Summary of epistatic interactions affecting the tumor and metastatic traits in male and female mice. Shown are the locations (Loc1 and Loc2) on each pair of chromosomes (Ch1 and Ch2) of the individual diet independent epistatic interactions affecting the tumor and metastatic traits that reached significance at the 0.05 (bolded values) or the 0.2 (suggestive) genomewise levels. Significant and suggestive threshold LOD scores are given in parentheses in the headings for each trait. Epistatic components (aa, ad, da, dd) that reached significance at P <0.05 are indicated by asterisks and their cumulative percentage (%) contribution to the phenotypic variance of each trait are given.