Column1 n premature birth postmature birth SGA LGA weight/height 3-97 P at   the age of 2 years delayed milestones at the age of 2 years Congenital or genetic disease NT ≥ 3.0 mm (3.0 - 4.5 mm) 5 1 0 0 1 5 0 0 extreme value in one marker 20 2 4 2 0 19 2 2* extreme value in ≥ 2 markers 10 1 0 4 0 7 3 2**   35 4 (11.4%) 4 (11.4%) 6 1 31 5 (14.3%) 4 (11.4%) SGA – small for gestational age LGA – large for gestational age * – one congenital heart disease, one congenital adrenal hyperplasia ** – one congenital heart disease, one Silver-Russell syndrome

Table 3: Postnatal outcome in children born after marked changes in maternal screening tests during pregnancy.