Initials Age at assessment (months) Full term birth Birth weight 10th-90th percentiles Weight at assessment 3rd-97th percentiles Height at assessment 3rd-97th percentiles Delayed milestones ≥3 dysmorphic features Congenital malformations Karyotype NT ≥3 mm Changes in serum markers* Further diagnostics S.S 21 Post term + + +           1   G.V 24 + + >97 >97 +     46,XY   2   EG.N 17 Post term + + +       46,XX   1   J.J 25 + + + +           1   KH.L 18 + + + +           2   T.S 22 + + + + +         1   A.A 21 + + + +   +       1   LL.H 28 + + <3 +       46,XX   1   M.R 31 Preterm + + +           2   R.R 26 + SGA + +       46,XY   1   M.L 23 + + + +           2   A.T 27 + + + +           1   ML.P 23 + + + +       46,XX   1   M.K 26 + + + +   +       1   R.T 30 + + +     +   46,XY   1   L.A 20 + SGA + +           1   R.V 24 + + + +       46,XY   1   K.H 20 Preterm SGA <3 + + + ASD 46,XX   2 + M.H 24 + + + +       46,XX +     E.M 23 + SGA + +   +   46,XX   1   K.T 26 + + + +   +       2 + T.T 20 + + + +           1   M.S 21 + + + +       46,XX   1   HM.A 19 + + + +       46,XX +     E.J 26 + + + +       46,XX   1   M.K 20 Post term + + +       46,XY   1   J.A 21 Post term + + +       46,XY   1   K.Š 28 Preterm + + +   +     +     E.S 33 + + + +   +   46,XX +   + MM.K 22 + SGA + + + + VSD, PDA 46,XX   1 + K.V 23 + + + +   +   46,XX   1 + S.O 20 + LGA + +   +   46,XY +   + R.K 21 + + + +           1 + M.M   + +         CAH 46,XY   1 + AK.K   Preterm SGA     + + SRS 46,XX   3   SGA=Small for Gestational Age; LGA=Large for Gestational Age ASD=Atrial Septal Defect; VSD=Ventricular Septal Defect; PDA= Patent Ductus Arteriousus; CAH=Congenital Adrenal Hyperplasia; SRS=Silver-Russell syndrome * previously described changes in first and second trimester screening, number indicating how many markers were affected

Table 4: The data of 35 evaluated cases: the age of evaluation, the results of clinical evaluation and the information of additional investigations.