Citation Sample Ethnicity Tissue Findings Number of Sites available in GENOA Number (%) of Sites with Same Direction of Effect and p<0.05 in GENOA
Bocklandt et al. [22] Monozygotic twins (N=34 pairs), ages 21-55 years Not specified Saliva 88 CpG sites at q-value<0.05 (absolute correlation>0.57) 87 65 (84%)
Alisch et al. [23] Males ages 3-17 years (N=398) 81% Caucasian, 1% African American, 4% Asian, 14% Other/NA Peripheral blood cells 2,078 CpG sites at FDR<0.01 2,022 1,465 (73%)
Numata et al. [24] Fetal (N=30) 40% Caucasian, 60% African American Dorsolateral frontal cortex 865 at FDR<0.05 (top 99 reported in supplemental material) 96 12 (13%)
  Childhood, ages 0-10 years (N=15)     5,506 at FDR<0.05 (top 99 reported in supplemental material) 99 49 (49%)
  Age>10 to 83 years (N=63)     10,578 at FDR<0.05 (top 99 reported in supplemental material) 99 63 (63%)
Teschendorff et al. [25] Post-menopausal women, ages 50-84 years (N=113 ovarian cancer cases; N=148 controls) Not specified Whole blood 589 at FDR<0.05 583 499 (86%)
Note: All studies measured methylation using the Illumina Infinium HumanMethylation27 BeadChip
Table 4: Comparison of age-associated methylation sites between GENOA and previous studies.