| Pathology features |
Lymphocytes infiltration and lymphoid aggregates in portal region; piecemeal necrosis; progressive fibrosis; steatosis |
Fibrous scars bridging portal tracts to each other or to central veins; fibrosis surround regenerating nodules of hepatocytes, liver cell plate thickened (Masson trichrome stain and reticulin stain for visualization of collagen and reticulin); variable inflammatory infiltration |
Increased nuclear to cytoplasm ratio; necrosis; steatosis |
| Differential diagnosis |
Hepatitis B, autoimmune hepatitis, PBC*, PSC*, Wilson’s disease; α1-antitrypsin deficiency |
Focal nodular hyperplasia; hemochromatosis; Wilson’s disease; α1-antitrypsin deficiency; congenital hepatic fibrosis |
Low grade dysplastic nodule; high grade dysplastic nodule |
