| Thrombophilic defect |
Prevalence in the white population (%) |
Normal population |
Relative Thrombotic Risk |
| Incident VTEa |
Recurrent VTE |
| Antithrombin deficiency [7,8,30] |
1-2 |
2-5 |
0.02-0.04 |
5-10 |
Protein C deficiency
[7,8,30,31] |
2-5 |
5-10 |
0.2-0.5 |
6-10 |
Protein S deficiency
[7,8,30] |
1-3 |
5-10 |
0.1-1 |
2-10 |
Factor V Leiden
[10,11,12] |
20 |
40-50 |
3-7 |
3-7 (heterozygotes)
50-100 (homozygotes) |
Prothrombin G20210A
[25,26,27] |
3-8 |
15-20 |
1-3 |
2-8 (heterozygotes) |
a VTE is abbreviated for venous thromboembolism |
