| |
Hematological indicators
Mean ± SE values |
% HbA2Mean ± SE |
Osmotic Fragility |
% Hb F |
Abnormal haemoglobin Quantity in %
Mean ± SE |
| RBC |
HGB |
HCT |
MCV |
MCH |
MCHC |
Reduced
(%) |
Normal
(%) |
| HbD*
N = 28 |
4.49
± 0.21 |
12.06
± 0.63 |
34.28
± 1.79 |
73.34
± 3.54 |
25.87
± 1.30 |
33.96
± 1.60 |
2.66
± 1.14 |
8 (33.30) |
16 (66.70) |
0.61 |
28.07
± 1.67 |
| HbQ**
N =6 |
4.49
± 0.21 |
11.30
± 1.30 |
34.22
± 2.33 |
76.58
± 6.33 |
25.24
± 2.64 |
32.80
± 1.13 |
3.50
± 0.49 |
2 (33.33) |
4 (66.67) |
ND |
9.86
± 0.60 |
| β thal
N = 217 |
5.76
± 0.08 |
11.20
± 0.15 |
34.76
± 0.53 |
60.81
± 0.71 |
19.80
± 0.34 |
33.12
± 1.08 |
5.99
± 0.09 |
213 (98.20) |
4 (1.80) |
1.23 |
-- |
Individual cases of double heterozygotes for abnormal hemoglobin and β thalassaemia
HbD-β thal$ |
|
| Case G1 |
5.05 |
11.90 |
35.20 |
69.70 |
23.60 |
33.80 |
4.50 |
Reduced |
0.40 |
81.30 |
| Case L2 |
4.04 |
12.40 |
30.50 |
73.00 |
27.70 |
38.00 |
7.80 |
Reduced |
ND |
88.00 |
| Case S3 |
5.75 |
8.90 |
27.50 |
48.00 |
15.50 |
32.40 |
5.90 |
Reduced |
2.00 |
92.00 |
|
HbQ- β thal$ |
| Case L4 |
4.12 |
9.40 |
32.40 |
77.10 |
22.40 |
29.00 |
5.50 |
Reduced |
0.80 |
9.90 |
Figures in the parentheses ( ) represent, percentage, ND: Not Detected, P: Present
* Haematology could not be performed on one sample with HbAD, osmotic fragility could be performed on only 24 HbD subjects
** Hematology could be performed on only 5 samples out of total 6 HbQIndia heterozygote cases.
# Indicates the presence of the abnormal hemoglobin
$ Samples are drawn from pooled population and are not unrelated subjects.
HbF quantified by 1 minute denaturation method
Students’‘t’ test between the quantity of HbD and HbQIndia = 10.26. P < 0.05 |
