| Personal history
|
Family history |
| early onset of cancer diagnosis: breast cancer < 45 years, colorectal cancer < 50 years, etc. |
three close relatives (same side of family) with cancer of the same or syndromically related type (breast/ovary, colorectal/endometrium |
| multiple associated primary cancers: breast/ovary, colorectal/endometrium |
two close relatives (same side of family) with cancer of the same or related type with at least one affected under 50 years |
| male breast cancer |
one first-degree relative with early onset cancer (breast < 45 years, colorectal < 50 years) |
| ovarian, fallopian tube, primary peritoneal cancer |
one fist-degree relative with multiple primary cancers |
| breast cancer and: thyroid, sarcoma, adrenocortical carcinoma |
Two or more relatives with uncommon cancers (sarcoma, glioma, hemangioblastoma, etc.) |
| multiple colon polyps (>10 cumulative) |
relatives of patients with known BRCA, APC, MYH, Lynch syndrome mutations |
| colorectal or endometrial cancer with lack of expression by immunohistochemistry for mismatch repair protein |
many relatives with cancer but no criteria for testing |
