Clinical criteria/cancer(s) included Model(s) Gene(s) included Syndrome Breast cancer (age<45, two primaries, male) Ovarian cancer Pancreatic cancer Prostate cancer Ashkenazi ancestry Family history Couch [5] Penn II [6] Myriad [7] BRCAPRO [8-10] Tyrer-Cuzick [11] BOADICEA [12] BRCA1 BRCA2 HBOC Amsterdam I and II [17] Bethesda [18] Colorectal cancer Endometrial cancer Wijnen [13] MMRpro [14] MMRpredict [15] PREMM1,2,6 [16] MLH1 MSH2 MSH6 Lynch/HNPCC Classic [19] Chompret [20] Adrenocortical, breast, sarcoma, brain cancer   TP53 Li-Fraumeni Classic [21] Cleveland clinic [22] PTEN Cowden Melanoma MELApro [23] CDKN2A Melanoma Hereditary Breast and Ovarian Cancer

Table 3: Clinical criteria guidelines and mutation probability models utilized for HCRA.