E-cadherin extracellular domain is fused with the Fc domain of IgG to generate
E-cadherin-Fc biomaterial (A). E-cadherin-Fc N-terminal domains display
homophilic binding with cell-resident E-cadherin while the Fc-domain binds
with polystyrene surface via hydrophobic interaction (B). Cell-cooking plate
technology has been successfully applied for desired cell culture (C) and in-situ cell sorting (D). Purified cells from the system can be applied for tissue
engineering (E) and regenerative medicine (F). |
