| miRNA |
Role in invasion/metastasis |
Cancer type |
Target |
| miR-9 |
metastasis |
colon, melanoma, head, neck |
REST, COREST |
| miR-10a |
promotion |
pancreatic |
HOXB1, HOXB4 |
| miR-10b |
promotion |
breast, glioblastoma,
esophageal, nasoparyngeal |
HOXD10, KLF4, LMP1, BCL2L11/Bim TFAP2C/AP-2g, CDKN1A/p21, CDKN2A/p16 |
| miR-15a |
suppression |
prostate |
BCL-2 |
| miR16 |
suppression |
prostate |
CDK1, CDK2 |
| miR17-92 |
promotion |
breast, coloreactal |
CTGF, TSP1 |
| miR21 |
promotion |
breast, colorectal, gastric, lung, pancreatic, prostate, bladder, ovarian , hepatocellular |
PDCD4, PTEN, CDC25A, RHOB, TIAMI, TPM1, TPM1, MARCKS, NF1B, SPRY2 |
| miR-22 |
suppression |
breast |
CDK6, SIRT1, SP1 |
| miR-25 |
promotion |
|
BIM, BAX and CASPASE-3 |
| miR-27a |
promotion |
breast |
APC, FOXO1 |
| miR-31 |
suppression |
breast |
RHOA, RDX, ITGA5 |
| miR-34a |
suppression |
gastric |
SIRT1-p53 pathway |
| miR34b and miR34c |
metastasis |
many different tumor types |
TCL1 |
| miR-122 |
suppression |
hepatocellular |
ADAM17, RHOA, RAC1 |
| miR-124a |
suppression |
colon, gastric, haematological |
SCP1, PTBP1 |
| miR-126 |
suppression |
breast, lung |
CRK, VEGF |
| miR-129-2 |
suppression |
colon, endometrical, gastric |
CDK4, SOX4, GALNT1, APC, RAB11, EIF2C3, CAMTA1 |
| miR-137 |
suppression |
colon, head and neck |
LSD1, CDK6, CDC42, MITF |
| miR-141 |
promotion |
colon, breast, lung, ovary |
p38a |
| miR-146a/b |
suppression |
breast, pancreatic, glioma, prostate, gastric |
EGFR, ROCK1, IRAK1, NFKB1 |
| miR148a |
metastasis |
colon, melanoma, breast |
BCL-2 |
| miR-151 |
metastasis |
hepatocellular carcinoma |
RHOGDIA |
| miR-194 |
suppression |
liver |
CDH2, DNMT3A, HBEGF |
| miR-196b |
dual roles
(suppression/promotion) |
gastric, leukemia |
HOXA9/MEIS1, FAS |
| miR-200c |
suppression |
colon, breast, lung |
ZEB1, ZEB2 |
| miR-205 |
suppression |
bladder , breast, prostate |
ERBB3, E2F1, E2F5, VEGF-A, IL24, IL32, ZEB1, ZEB2 |
| miR-206 |
suppression |
breast, rhabdomyosarcoma |
ESR1, MET |
| miR-214 |
promotion or suppression |
melanoma |
TFAP2C, MAP2K3, MAPK8 |
| miR-335 |
suppression |
gastric, breast |
BCL2L2, SP1, SOX4, TNC |
| miR-373 |
metastasis |
breast, testicular germ cell |
CD44, LAST2 |
| miR-378 |
promotion |
breast, glioblastoma |
SUFU, FUS-1 |
| miR-517c/miR520g |
promotion |
neuroectodermal brain tumor |
WNT upregulation |
| miR-520c |
metastasis/invasion |
breast |
CD44 |
|
