Figure 1: Semi-logarithmic concentration-time profile for total plasma, muscle, and subcutaneous tissue cefazolin concentrations over time for piglets that underwent cardiopulmonary bypass with deep hypothermic circulatory arrest (CPB+DHCA, n=4). The horizontal lines indicate various concentration targets and associated SSI pathogen(s). Vertical arrows labeled with “*” represent the initiation of CPB (30 minutes) and the end of CPB (various times) for each subject. Vertical arrows labeled with “#” represent the initiation of DHCA (60 minutes) and end of DHCA (150 minutes) for each subject. Abbreviations: μg: microgram; mL: milliliter; MSSA: methicillin sensitive Staphylococcus aureus ; E: Escherichia; K: Klebsiella ; S: Staphylococcus ; sp: species.