Time point of observation Heart rate (Beats/min) p value* NIBP (mm Hg) p value* Respiratory rate (times/min) p value* SpO2 (%) p value*
Baseline 106.8±11.47   98.40±18.40   20.00±4.40   97.90±1.66  
5 minutes 106.70±8.99 1.00 96.30±16.32 0.87 20.30±2.54 1.00 98.50±1.27 1.00
10 minutes 108.10 ±8.88 1.00 98.00±17.28 1.00 21.70±3.65 1.00 98.10±1.79 1.00
15 minutes 103.60±9.26 1.00 93.90±12.97 0.71 21.70±4.47 1.00 95.80±7.13 1.00
20 minutes 105.20±9.58 1.00 93.60±14.51 0.69 21.90±4.09 1.00 98.40±1.43 1.00
25 minutes 106.13±9.43 1.00 88.00±10.69 0.09 20.25±2.82 1.00 98.75±1.49 1.00
30 minutes 104.63±15.54 1.00 89.38±13.19 0.1 20.63±3.02 1.00 98.63±2.00 1.00
35 minutes 117.25±12.89 0.944 98.75±11.59 1.00 23.75±1.26 1.00 97.75±3.86 1.00
40 minutes 113.00±15.39 0.935 96.67±8.02 0.94 21.67±2.08 1.00 99.00±1.00 1.00
45 minutes 90.00 ±0.00 1.00 98.00 ±0.00 1.00 20.00±0.00 1.00 100.00±0.00 1.00
Table 2: Variations in Vital signs during treatment progression at 5 minute intervals; *calculated on the basis of repeated measures of ANOVA.