Study N of patients Stimulation parameters N of pulses / session N of sessions Outcome measure Pascual-Leone et al., [29] 6 5 Hz – 10% RMT n.a. 3 Movement time; reaction time Siebner et al., [30] 12 5 Hz – 90% RMT 750 2 Movement time Ghabra et al., [31] 11 5 Hz – 90% RMT n.a. 2 Grooved Pegboard test (Fine movement) Tergau et al., [32] 7 1/ 5/ 10/ 20 Hz – 90% MT 500 1 UPDRS-III; reaction time Siebner et al., [33] 10 5 Hz – 90% RMT 2250 1 UPDRS-III De Groot et al., [34] 9 5 Hz – 90% RMT 2250 1 UPDRS-III; movement time Sommer et al., [35] 11 1 Hz – 120% RMT 900 3 Movement time Okabe et al., [36] 85 0.2 Hz – 110% AMT 100 8 UPDRS-III Khedr et al., [37] 19 5 Hz – 120% MT 2000 10 UPDRS-III Bornke et al., [38] 12 10 Hz – 90% RMT 1000 2 UPDRS-III Lefaucher et al.,[39] 12 0.5 / 10 Hz – 80% RMT 600 / 2000 1 UPDRS-III Khedr et al., [40] 35 10 / 25 Hz – 100% RMT 3000 6 UPDRS-III Lomarev et al., [41] 18 25 Hz – 100% RMT 1200 8 UPDRS-III Khedr et al., [42] 20 25 Hz – 100% RMT 3000 6 UPDRS-III Rektorova et al., [43] 6 10 Hz – 90% RMT 1350 5 UPDRS-III; FOG Kim et al., [44] 9 5 Hz – 90% RMT 75 2 UPDRS-III Rothkegel et al., 2009 22 0.5 / 10 Hz – 80% RMT 600 / 2000 1 Pointing; pronation supination; Purdue Pegboard Test Gruner et al., [46] 15 1 Hz – 90% RMT 1800 4 Movement frequency Filipovic et al., [47] 10 1 Hz – 90% RMT 1800 4 UPDRS-III Kodama et al., [48] 1 0.9 Hz – 110% AMT 200 – 600 20 UPDRS-III González-García et al., [49] 10 25 Hz- 80% RMT 200 15 UPDRS-III Benninger et al.,[50] 13 50 Hz – 80% AMT 600 8 UPDRS-III Maruo et al., [51] 21 10 Hz – 100% RMT 1000 3 UPDRS-III Von Papen et al., [52] 10 1 Hz – 80% RMT 900 1 Gait kinematics Spagnolo et al., [53] 27 10 Hz – 90% RMT 1680 12 UPDRS-III

Table 1: rTMS studies in PD: M1 as target area. rTMS, repetitive Transcranial Magnetic Stimulation; PD, Parkinson’s Disease; M1, Primary Motor Cortex; Hz, Hertz; MT, Motor Threshold; AMT, Active Motor Threshold; UPDRS (III), Unified Parkinson’s Disease Rating Scale (Section III); FOG, Freezing of Gait.