Genotypes Alleles GG N (%) AG N (%) AA N (%) G N (%) A N (%) Control (20) 8 (40%) 7 (35%) 5 (25%) 23 (57.5%) 17 (42.5%) Asthmatics (80) 6 (7.5%) 49 (61.2%) 25 (31.3%) 61 (38%) 99 (62%) P 0.0007* 0.03* 0.5 0.02* 0.02* OR (95%CI) 0.12 (0.03-0.4) 2.9 (1.1-8.1) 1.4 (0.4-4.2) 0.4 (0.2-0.9) 2.2 (1.1-4.4) Positive family history (54) 4 (7.4%) 36 (66.7 %) 14 (25.9%) 44 (40.8%) 64 (59.2%) P 0.002* 0.01* 0.9 0.07 0.07 OR (95%CI) 0.1 (0.03-0.5) 3.7 (1.3-11) 1.05 (0.3-3.4) 0.5 (0.2-1.1) 1.9 (0.9-4.1) Positive allergic rhinitis (39) 3 (7.7%) 26 (66.7%) 10 (25.6%) 32 (41%) 46 (59%) P 0.005* 0.02* 0.9 0.09 0.09 OR (95%CI) 0.1 (0.02-0.5) 3.7 (1.2-11.5) 1 (0.3-3.6) 0.5 (0.2-1.1) 1.9 (0.9-4.2) Positive eczema (21) 2 (9.5%) 13 (61.9%) 6 (28.6%) 17 (40.5%) 25 (59.5%) P 0.03* 0.08 0.7 0.1 0.1 OR (95%CI) 0.1 (0.02-0.9) 3 (0.8-11) 1.2 (0.3-5) 0.5 (0.2-1.2) 2 (0.8-4.8)

Significance using fisher's exact test. *Statistical significance was defined as P ≤0.05 Table 3: Frequency of IL-4RA 175V genotype and allelic polymorphisms among asthmatic cases compared to controls.