| Cough group |
SOB group |
Cough with SOB group |
Control |
|
| IL4RA175V |
IL-9 |
IL4RA175V |
IL-9 |
IL4RA175V |
IL-9 |
IL4RA175V |
IL-9 |
|
| G/G (n=3) |
29±3 |
G/G (n=0) |
|
G/G (n=3) |
88±58 |
G/G (n=8) |
18±4.7 |
P=0.009* |
| A/G (n=12) |
25 ± 11 |
A/G (n=18) |
35±17 |
A/G (n=20) |
39±29 |
A/G (n=7) |
34±14 |
P=0.1 |
| A/A (n=5) |
28±17 |
A/A (n=12) |
29±11 |
A/A (n=9) |
85 ± 65 |
A/A (n=5) |
42± 15 |
P=0.05* |
| |
P=0.8 |
|
P=0.7 |
|
P=0.3 |
|
P=0.4 |
|
| IL4C-590T |
IL-17 |
IL4C-590T |
IL-17 |
IL4C-590T |
IL-17 |
IL4C-590T |
IL-17 |
|
| C/C (n=3) |
267 ± 109 |
C/C (n=3) |
263 ± 240 |
C/C (n=3) |
65 ± 50 |
C/C (n=4) |
79 ± 7.1 |
P=0.2 |
| C/T (n=15) |
120 ± 88 |
C/T (n=17) |
108 ± 72 |
C/T (n=24) |
154 ± 146 |
C/T (n=14) |
88 ± 15 |
P=0.3 |
| T/T (n=2) |
57 ± 28 |
T/T (n=10) |
129 ± 73 |
T/T (n=5) |
137 ± 65 |
T/T (n=2) |
103 ± 38 |
P=0.5 |
| |
P=0.06
P∏=0.04* |
|
P=0.5 |
|
P=0.3 |
|
P=0.5 |
|
|
| Results are expressed as mean ± Standard deviation.P value based on one way ANOVA, and independent sample T test *Statistical significance was defined as P ≤ 0.05. PΠ for difference between CC, CT is significant (0.04*) |
|
Table 4: Serum levels of IL-9 and IL-17 cytokines (pg/ml) in individuals with different genotypes of the IL-4RA 175V and IL-4C-590T genes in the three asthmatic phenotypes. |
