| (A) |
| SNPs loci |
|
| Genotype |
OR (95%CI), P-value |
| Intron 2 A>T |
|
| AA |
1 |
| AT/TT |
1.285 (0.818 – 2.016), 0.276 |
| Exon 4 T>C |
|
| TT |
1 |
| TC/CC |
1.724 (1.087 – 2.732), 0.021 |
|
| (B) |
| SNPs loci |
Male |
Female |
| Genotype |
OR (95%CI), P-value |
OR (95%CI), P-value |
| Intron 2 A>T |
AA
AT/TT |
1 |
1 |
| 1.315 (0.564 – 3.070), 0.526 |
1.280 (0.751 – 2.181), 0.365 |
| Exon 4 T>C |
TT
TC/CC |
1 |
1 |
| 3.177 (1.311 – 7.699), 0.010 |
1.368 (0.792 – 2.363), 0.261 |
|
| aMultivarible logistic regression analysis was applied for age and
gender (A) and age (B) as covariables. Values in bold indicate
significant P-Value. SNP: Single Nucleotide polymorphism; OR: Odds
Ratio; CI: Confidence Interval. |
| Table 3: Multivariable logistic regression analysis (A) and the
subgroup analysis with gender (B) of genotype of the intron 2 A>T
and exon 4 T>C gene in Japanese patients with aspirin-exacerbated
respiratory disease compared with those with aspirin-tolerant asthmaa. |
