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 Research Article Open Access 
Effect of Anthum Graveolens L. Extract on Biochemical and Histopathological Alteration of Deltamethrin in Rats
Somia I. El-Maghraby1*, Hamdy A. Taha1 and Nabila S. Hassan2
1Department of Applied Organic Chemistry, National Research Center, Dokki, Giza, Egypt
2Department of pathology, National Research Center, Dokki, Giza, Egypt
*Corresponding author: Somia I. El-Maghraby,
Assistant professor in NRC,
Department of Applied Organic Chemistry,
National Research Center, Dokki, Giza, Egypt
Fax: +202 33370931,
E-mail: [email protected]
 
Received February 05, 2010; Accepted March 13, 2010; Published March 13, 2010
Citation: El-Maghraby SI, Taha HA, Hassan NS (2010) High Performance Liquid Chromatographic Method for the Determination of Clobetasol in Rat Plasma and its Application to Skin Penetration. J Bioanal Biomed 2: 008-012. doi:10.4172/1948-593X.1000014
 
Copyright: © 2010 El-Maghraby SI, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 
Abstract
Anthum graveolens (dill) seeds are a common and very effective household remedy for a wide range of digestive problems. The present study was performed to investigate the effect of dill extracts on altered biochemical parameters in deltamethrin-exposed rats. Deltamethrin was administered orally at doses 7.5 and 15 mg /kg of body weight on the basis of LD50 for 30 days. The sub-acute toxicity of pyrethroid insecticide deltamethrin varies markedly with the dose employed. Oral administration of plant extracts to rats for 30 days afforded a good protection against deltamethrin elevation in serum marker enzymes. They decreased the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) which was increased by DLM administration. Deltamethrin significantly increased the level of plasma total protein (TP), cholesterol and triglyceride. The concentration of urea and creatinine were also increased and all these parameters were decreased by the effect of plant extract. Results were also indicated that, the enzyme activities of acetyl cholinesterase (AchE), catalase (Cat) and glutathione-S-transferase (GST) were increased as compared to the DLM group. Dose dependant of histopathological changes which observed in both liver and kidney are also described.
 
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