| Research Article |
Open Access |
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| The Pharmacokinetics Evaluation and Bioequivalence of new Docetaxel Injections and Taxotere using Healthy Rats |
| Rong Wang, Xiao-Yu Wu, Hua Xie, Juan-Hong Zhang, Jun Ma, Xia-Dong Men,
Juan Wang, Jun-Li Zhang, Wen-Bing Li and Zheng-Ping Jia* |
| Department of Pharmacy, Lanzhou General Hospital of PLA, Lanzhou, China |
| *Corresponding author: |
Zheng-Ping Jia,
Department of Pharmacy,
Lanzhou General Hospital of PLA,
Lanzhou, China
Email: wangrong-69@163.com |
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| Received February 26, 2010; Accepted March 17, 2010; Published March 17, 2010 |
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Citation: Wang R, Wu XY, Xie H, Zhang JH, Ma J, et al. (2010) The Pharmacokinetics Evaluation and Bioequivalence of new Docetaxel Injections and Taxotere using Healthy Rats. J Bioanal Biomed 2: 023-027. doi: 10.4172/1948-593X.1000017 |
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Copyright: © 2010 Wang R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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| Abstract |
| The docetaxel of sterile freeze-dried powder injections was
of Taxotere. We has been evaluated the pharmacokinetic
properties and bioequivalence of the docetaxel of sterile
freeze-dried powder injections and Taxotere by highly selective
and accurate LC-MS/MS method in healthy rats.
The pharmacokinetic parameters and bioequivalence of two
injections were obtained by the profession software (DAS,
version 2.0). The 90% CIs for the In-transformed ratios of
Cmax: AUC0-t and AUC0~8 were 101.3%-104.1%, 99.8%
100.8% and 99.4-100.6%, respectively (all, p < 0.001). In
this study, we attained the pharmacokinetic parameters of
the two injections’, meanwhile docetaxel of sterile freezedried
powder injections appeared to be bioequivalent to
Taxotere in healthy rats. The result was beneficially to further
study the pharmacokinetics and bioequivalence of the
human in the future research. |
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