Journal Details
 Research Article Open Access 
The Pharmacokinetics Evaluation and Bioequivalence of new Docetaxel Injections and Taxotere using Healthy Rats
Rong Wang, Xiao-Yu Wu, Hua Xie, Juan-Hong Zhang, Jun Ma, Xia-Dong Men, Juan Wang, Jun-Li Zhang, Wen-Bing Li and Zheng-Ping Jia*
Department of Pharmacy, Lanzhou General Hospital of PLA, Lanzhou, China
*Corresponding author: Zheng-Ping Jia,
Department of Pharmacy,
Lanzhou General Hospital of PLA,
Lanzhou, China
Email: [email protected]
 
Received February 26, 2010; Accepted March 17, 2010; Published March 17, 2010
 
Citation: Wang R, Wu XY, Xie H, Zhang JH, Ma J, et al. (2010) The Pharmacokinetics Evaluation and Bioequivalence of new Docetaxel Injections and Taxotere using Healthy Rats. J Bioanal Biomed 2: 023-027. doi:10.4172/1948-593X.1000017
 
Copyright: © 2010 Wang R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 
Abstract
The docetaxel of sterile freeze-dried powder injections was of Taxotere. We has been evaluated the pharmacokinetic properties and bioequivalence of the docetaxel of sterile freeze-dried powder injections and Taxotere by highly selective and accurate LC-MS/MS method in healthy rats. The pharmacokinetic parameters and bioequivalence of two injections were obtained by the profession software (DAS, version 2.0). The 90% CIs for the In-transformed ratios of Cmax: AUC0-t and AUC0~8 were 101.3%-104.1%, 99.8% 100.8% and 99.4-100.6%, respectively (all, p < 0.001). In this study, we attained the pharmacokinetic parameters of the two injections’, meanwhile docetaxel of sterile freezedried powder injections appeared to be bioequivalent to Taxotere in healthy rats. The result was beneficially to further study the pharmacokinetics and bioequivalence of the human in the future research.
 
This Article
DOWNLOAD
» Full Text (PDF)
» Full Text (HTML)
   
Services
» Similar articles in google scholar
» Similar articles in Pub Med
   
Google Scholar
Articles by
» Rong Wang
» Xiao-Yu Wu
» Hua Xie
   
Pub Med
Articles by
» Rong Wang
» Xiao-Yu Wu
» Hua Xie
   
OMICS Publishing Group is the member of/publishing partner of/source content provider to