| Research Article |
Open Access |
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| Effect of Induced Mastitis on Disposition Kinetics of Gatifloxacin Following Intravenous Administration in Goats |
| Vishakha Singh1, Mahendra Ram1, Birendra Kumar Roy1* and Kaushal Kumar Singh2 |
1Dept. of Pharmacology & Toxicology, College of Veterinary Science & A. H., Ranchi -834006, Jharkhand, India
2Dept. of Veterinary pathology, College of Veterinary Science & A. H., Ranchi-834006, Jharkhand, India |
| *Corresponding author: |
Dr. B. K. Roy,
Dept. of Pharmacology & Toxicology,
College of Veterinary Science & A. H.,
Ranchi – 834006, Jharkhand, India,
Tel: +91-651-2450759;
Fax: +91 -651-2450759;
E-mail: roybk2001@yahoo.co.in |
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| Received March 23, 2010; Accepted April 25, 2010; Published April 25, 2010 |
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| Citation: Singh V, Ram M, Roy BK, Singh KK (2010) Effect of Induced Mastitis on Disposition Kinetics of Gatifl oxacin Following Intravenous Administration in Goats. J Bioanal Biomed 2: 044-048. doi: 10.4172/1948-593X.1000020 |
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| Copyright: © 2010 Singh V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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| Abstract |
| Disposition kinetic studies of gatifl oxacin (GAT) was conducted after single i.v. dose (10 mg/kg) in six healthy and
six mastitic Black Bengal lactating goats. Mastitis was induced by coagulase positive S. aureus. The concentration
of the drug was estimated by HPLC. The maximum milk concentration was found to be signifi cantly (p< 0.05) higher
in mastitic goats (12.78 ± 3.11 μg/ml) than healthy (9.17 ± 1.41 μg/ml). The therapeutic milk concentration in mastitic
goats (0.13 ± 0.05 to 12.41 ± 2.99 μg/ml) was maintained for 48 h which was signifi cantly (p<0.01) longer than in
healthy goats (24 h). The elimination half-life in plasma and milk of mastitic goats (5.82 ± 0.67 and 8.20±0.21 h) was
signifi cantly (p<0.01) higher than healthy (4.54 ± 0.75 and 3.67±0.09 h).It indicates that GAT persisted in the body of
mastitic goats for a longer duration. The AUCmilk/AUCplasma ratio was 5.82. The t½ milk /t½ plasma ratio was 1.41. MIC
in this experiment was considered to be 0.1 μg/ml. The AUC/MIC ratio of plasma and milk of mastitic goats were 180 and
1049 respectively. On the basis of the results obtained it was concluded that GAT exhibited improved pharmacokinetic
parameters with good penetration and longer persistence in mastitic milk, which will be of great help in the treatment of
mastitis in goats caused by S. aureus. |
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