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 Research Article Open Access 
Bioencapsulation of Florfenicol in Brine Shrimp, Artemia Franciscana, Nauplii
1Institute of Marine Research, P.O. Box 1870 Nordnes, N-5817 Bergen, Norway
2SagaFjord Sea Farm AS, Eldøyane 200, 5411 Stord, Norway
3Section of Pharmacology, Institute of Internal Medicine, University of Bergen, Armauer Hansens Hus, 5021 Bergen, Norway
*Corresponding author: Dr. Ole Bent Samuelsen,
Institute of Marine Research,
P.O. Box 1870 Nordnes,
N-5817 Bergen, Norway,
Fax: +47 55 23 85 31
E-mail: [email protected]
 
Received May 14, 2010; Accepted June 25, 2010; Published June 25, 2010
Citation: Roiha IS, Otterlei E, Samuelsen OB (2010) Bioencapsulation of Florfenicol in Brine Shrimp, Artemia Franciscana, Nauplii. J Bioanal Biomed 2: 060- 064. doi:10.4172/1948-593X.1000023
 
Copyright: © 2010 Roiha IS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 
Abstract
The brine shrimp Artemia franciscana is one of the most common live-feed organisms for use in the larval culture of marine fish production. Bioencapsulation of florfenicol, an antibacterial agent, in Artemia nauplii was investigated as a potential carrier for this drug to marine larvae. Florfenicol was delivered directly to the organisms as particles, and the doses ranged from 100 to 2000 mg/l. Analysis of florfenicol concentrations in Artemia sp. nauplii were performed using high performance liquid chromatography (HPLC). The uptake of florfenicol in Artemia nauplii increased with particle size, dose, and exposure time, obtaining the highest concentration of 5.02 ng/nauplius, using a dose of 300 mg/l AQUAFLOR premix and 10 min exposure time. However, to obtain reproducible results, an enrichment time of at least 60 min is recommended. 
 
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