Concentration   CV (%) % diff
TMP   SMX TMP SMX
 
Short term stability for 24 h in plasma at room temperature
Low 6.32   1.45 2.06 - 14.83% 0.78 - 3.36%
High 1.22   1.29 -3.57 - (-)1.46 % -0.16 - 2.19%
Long term storage at -20°C for 30 days
Low 3.95   9.18 -14.22 - (-)7.18% -7.17 - 10.57%
High 3.20   2.70 2.04 - 8.77 % -0.07 - 4.82%
Three freeze/thaw cycles
Low 0.64   3.31 -11.74 - (-)10.60% -10.80 - (-)5.51%
High 0.06   0.04 -13.92 - (-)3.75 % -11.56 - (-)4.08%
Table 2: Stability data of cotrimoxazole in human plasma.