Figure 2: Topology-overlap matrix (TOM)-based connectivity network in the TLR, TCR, and BCR signaling pathways. Top 3% of gene pairs with largest TOMbasedmeasures were selected to generate these networks. Red (yellow) dot: gene with significant increase (decrease) in expression in cases; circle: gene that is not differentially expressed between cases and controls. A: atherosclerosis; B: Ischemic Stroke; C: Myocardial Infarction.