Amino Acid

Side chain group

tBoc-strategy

Fmoc-strategy

Arg

R-NH-C=NH-NH2

Tos/Mts/NO2/tfa/Z/Alloc

Tos/Pmc/Pbf/Mts/Mtr/MIS/
bis-tBoc/Suben/Sub/MeSub/NO2/tfa/Z/Alloc

Asn

R-CONH2

Trt/Xan

Trt/Xan/Mtt/Cpd/Mbh/Tmob

Asp

RCOOH

OBzl/Bn/cHx/Men/Fmoc/Dmab/Al/
pNB/Dmnb

OtBu/Bn/cHx/tBu/Men/Mpe/
2-Ph-iPr/TEGBz/TEGBn/Dmab/Al/pNB/
PTMSE

Cys

R-SH

Meb/Mob/Bn/tBu/1-Ada/Fmoc/Dnpe/
Acm/PhAcm/StBu/Npys/S-Pyr/
Alloc/oNB/4-picolyl/Nin

Meb/Mob/Trt/Mmt/Tmob/Xan/Pmbf/Bn/tBu/
1-Ada/Acm/PhAcm/StBu/oNB/4-picolyl

Gln

R-CONH2

Trt/Xan

Trt/Xan/Mtt/Cpd/Mbh/Tmob

Glu

RCOOH

Bn/cHx/Men/Fmoc/Dmab/Al/pNB/
Dmnb

Bn/cHx/tBu/Men/Mpe/2-Ph-iPr/TEGBz/
TEGBn/Dmab/Al/pNB/PTMSE

His

Tos/Doc/Bom/Fmoc/Dmbz/Dnp

Trt/Mtt/Mmt/tBoc/Bom/Dmbz

Lys

R-NH2

Cl-Z/Z/Alloc/oNBS/dNBS/Troc/Dts/
pNZ/Poc/oNZ/NVOC/NPPOC/
MNPPOC/HFA/Fmoc/ivDde/tfa/Msc/
TCP/Phdec/Pydec/Ddiv

Cl-Z/tBoc/Z/Alloc/oNBS/Troc/pNZ/oNZ/
NVOC/NPPOC/MNPPOC/Azoc/Mtt/
ivDde/TCP/Phdec/Pydec

Met

R-S-CH3

tBu/Acm/StBu

Trt/Tmob/ Mmt

Ser

R-OH

Bn/cHx/TBDPS/Dmnb/Poc

Bn/cHx/tBu/Trt/TBDMS/Pseudoprolines/ TBDPS/Dmnb/Poc

Thr

R-OH

Bn/cHx

Bn/cHx/tBu/Trt/TBDMS/Pseudoprolines

Trp

For/Hoc/Mts/Alloc

tBoc/Hoc/Mts

Tyr

R-Ph-OH

Bn/Dcb/BrBn/Z/BrZ/Pen/Al/oNB/Poc

Bn/tBu/Dcb/BrBn/Pen/Trt/2-Cl-Trt/TBDMS/
TEGBz/TEGBn/Al/oNB/tBoc-Nmec

Table 1: Protecting groups for the side chains of different amino acids.