Circle identifies individual participant value and line identifies geometric means. ALO-02: extended-release oxycodone hydrochloride with sequestered naltrexone hydrochloride; AUCinf: area under the plasma concentrationtime profile from time 0 extrapolated to infinity; Cmax: maximum plasma concentration; IRO: immediate-release oxycodone.

Figure 2: Individual and geometric mean dose-normalized plasma oxycodone AUCinf (upper panel) and Cmax (lower panel) values by treatment following single oral doses of ALO-02 40 mg capsules and IRO 20 mg tablets.