(A) Sildenafil Test Reference Parameter (unit) Mean Range Mean Range Cmax (ng/ml) 411.83 152.70 – 851.38 447.83 176.09 – 1030.35 AUC0®last (ng.hr/ml) 1322.93 560.84 – 2562.09 1250.28 567.94 – 2301.67 AUC0®Inf(ng.hr/ml) 1405.92 621.11 – 2711.13 1328.27 616.21 – 2339.35 Parameter (unit) Median Range Median Range Tmax (hours) 0.75 0.50 – 2.25 0.75 0.25 – 4.00 T1/2 (hours) 3.52 2.11 – 4.87 3.44 2.14 – 5.80       (B) N-desmethyl Sildenafil Test Reference Parameter (unit) Mean Range Mean Range Cmax (ng/ml) 211.49 90.82 – 390.15 208.41 69.12 – 346.13 AUC0®last(ng.hr/ml) 726.63 666.31 – 1440.54 652.82 354.26 – 1262.08 AUC0®Inf(ng.hr/ml) 758.70 426.79 – 1471.22 687.28 372.24 – 1434.64 Parameter (unit) Median Range Median Range Tmax (hours) 0.88 0.50 - 2.00 0.88 0.50 – 4.00 T1/2 (hours) 5.64 4.13 – 8.43 5.81 4.03 – 15.07

Table 2: Pharmacokinetic parameters of sildenafil and its active metabolite N-desmethyl sildenafil after a single oral dose of 100mg sildenafil tablets under fasting conditions (n=30).