(A) Sildenafil Test Reference Parameter (unit) Mean Range Mean Range Cmax (ng/ml) 360.14 166.63 – 561.53 336.29 140.46 – 581.91 AUC0®last (ng.hr/ml) 1361.07 822.20 – 2818.85 1210.05 634.89 – 3150.15 AUC0®inf(ng.hr/ml) 1444.43 857.53 – 2844.49 1291.66 714.77 – 3314.72 Parameter (unit) Median Range Median Range Tmax (hours) 1.00 0.33 – 4.50 1.84 0.33 – 8.00 T1/2 (hours) 2.72 1.52 – 5.45 2.92 1.37 – 5.35       (B) N-desmethyl Sildenafil Test Reference Parameter (unit) Mean Range Mean Range Cmax (ng/ml) 168.91 83.89 – 362.34 158.60 64.55 – 406.17 AUC0®last(ng.hr/ml) 645.57 313.29 – 1667.71 561.65 260.71 – 1586.38 AUC0®inf(ng.hr/ml) 690.90 333.17 – 1773.97 615.48 291.65 – 1647.82 Parameter (unit) Median Range Median Range Tmax (hours) 1.33 0.67 – 4.50 2.00 0.67 – 4.50 T1/2 (hours) 3.75 1.98 – 6.38 3.95 1.92 – 8.38

Table 3: Pharmacokinetic parameters of sildenafil and its active metaboliteN-desmethyl sildenafil after a single oral dose of 100mg sildenafil tablets underfed conditions (n=32).