(A) Sildenafil prodrug No PK Parameter Point Estimate (Ratio of geometric mean %) Lower Limit Upper Limit CV (%) Power Result 1 AUC 0-last (ng.hr/ml) 105.646 97.036 115.016 19.353 95.239 BE 2 AUC0-inf (ng.hr/ml) 105.376 97.370 114.039 17.970 97.577 BE 3 Cmax (ng/ml) 94.446 85.029 104.905 24.399 83.928 BE (B) N-desmethyl Sildenafil (active metabolite) No PK Parameter Point Estimate (Ratio of geometric mean %) Lower Limit Upper Limit CV (%) Power Result 1 AUC 0-last (ng.hr/ml) 111.729 106.637 117.065 10.555 99.140 BE 2 AUC0-inf (ng.hr/ml) 111.320 105.610 117.339 11.923 97.932 BE 3 Cmax (ng/ml) 111.682 91.818 111.682 22.368 96.615 BE (c) Combination (sum of the parent drug and its active metabolite) No PK Parameter Point Estimate (Ratio of geometric mean %) Lower Limit Upper Limit CV (%) Power Result 1 AUC0-last (nM.hr) 92.842 87.105 98.957 14.468 98.814 BE 2 AUC0-inf (nM.hr) 92.705 86.912 98.884 14.637 98.533 BE 3 Cmax (nM) 102.662 93.358 112.892 21.683 96.299 BE

BE = Bioequivalent

Table 5: Statistical Result of sildenafil, its active metabolite n-desmethylsildenafil,and their combination under fasting conditions (n = 30).