Pharmacokinetic Parametre Diabetmin 250mg tablet (test) Mean ± sd Sunward Metformin 250mg (reference) Mean ± sd Cmax 434 ± 152.8 447 ± 119.7 AUC0-t 3097 ± 925.4 3252 ± 802.6 AUC0-∞ 3284 ± 935.4 3428 ± 826.9 Tmax (hr) 3.5 ± 0.71 2.9 ± 1.05 T1/2 (hr) 3.8 ± 1.29 3.5 ± 0.74 Ke (hr-1) 0.2± 0.06 0.2± 0.05

sd, standard deviation; AUC0-t, area under the plasma-concentration curve from dosing to last quantifiable time point; AUC0-∞, area under the plasma-concentration curve from dosing to infinity; Cmax, peak plasma concentration

Table 2: Pharmacokinetic parametre of the test Metformin formulation (Diabetmin) versus the reference formulation (Sunward Metformin) under fed condition. mean ± sd (n=21).