| Function of the involved genes |
Functional status in NK-neoplasms |
Gene |
Genetic aberration |
References |
| Tumor suppressor genes |
Down-regulated |
PRDM1 |
6q21-q22.1 (del6q21) |
[54-56,64-66] |
| FOXO3 |
6q21 |
[55-63] |
| ATG5 |
6q21 |
[54,66] |
| AIM1 |
6q21 |
[45,54,66] |
| HACE1 |
6q21-23 |
[45,48,55] |
| TNFAIP3 (A20) |
6q21-23 |
[55] |
| TP53 |
17p13.1 |
[82] |
| TP73 |
1p36.3 |
[84] |
| Cell signaling transducing pathways |
Up-regulated |
STAT3 |
17q21 |
[96,97] |
| JAK2 |
9p24 |
[45,48] |
| IL-10 |
1q31-q32 |
[111,112] |
| AKT1/2/3 |
14q32.3/19q13.1/1q44 |
[45,48,54] |
| NOTCH1 |
9q34.3 |
[45,101] |
| Β-CATENIN (WNT) |
3p22–p21.3 |
[48] |
| PDGFRA |
4q11–q13 |
[45,48] |
| PDGFA/B |
7p22/22q12.3–q13.1 |
[48] |
| Cell survival en apoptosis |
Down-regulated |
CCND3 |
6p21.1 |
[48] |
| SERPINB9 (PI9) |
6p25 |
[132,133] |
| TNFAIP3 |
6q23 |
[48] |
| FAS |
10q24.1 |
[102,103] |
| Up-regulated |
SURVIVIN (BIRC5) |
17q25.3 |
[74] |
| FASL |
1q23 |
[102,103] |
| Cell division |
Up-regulated |
AURKA |
20q13 |
[101] |
| Angiogenesis |
Up-regulated |
MET or HGFR |
7q31 |
[45,48] |
| VEGFR2 |
4q12 |
[45,48] |
| VEGFA |
6q12 |
[45,48] |
| HIF1α |
14q21–q24 |
[45,54] |
|
