PPT 3

Table 1: Published expert consensus recommendations available evaluating the utilization of MTHFR C677T testing for thrombosis and inherited thrombophilia

Professional Organization Year Type of Clinical Consensus Recommendations for stand-alone MTHFR C677T testing? Reflex testing in presence of elevated serum homocysteine (>13 umol/L)? ACMG 2001 Working Group Consensus Statement No No ACoG 2001 Practice Bulletin Guideline No No CAP 2002 Expert Consensus Recommendation No No AHA 205 Expert Recommendation No Yes-optional ACCP 2008 Clinical Guideline No No BHSC 2010 Clinical Guideline No No

ACMG: American College of Medical Genetics; ACOG: American College of Obstetrics and Gynecology; CAP: College of American Pathologist; AHA: American Heart Association; ACCP: American College of Chest Surgeons; BHSC: British Hematology Standards Committee; MTHFR: Methylene TetraHydroFolate Reductase