Type of reagent Marker B-Lineage T-Lineage   Early-     Pre-T T-ALL Pro-B Pre-B CALLA Pre-B B-ALL Against HLA-DR + + + + +/- - Precursor TdT (n) + + - - + - Cells CD34 + + - - - -   CD19(m) + + + + - -   CD22(c) + + + + - - Against CD10(m) - + + -/+ +/- - B-cell CD20 - - + + - - Antigens CD79a(c) + + + + - -   cIg (c) - - + + - -   sIg(m) - - - + - -   CD7 (m) - - - - + + Against CD3(c) - - - - + + T-cell CD5(m) - - - - +/- + Antigens CD2 - - - - - + HLA-DR: Human leukocyte antigen class II TdT: Terminal deoxynucleotide transferase cIg: cytoplasmic immunoglobulin sIg: surface immunoglobulin CD: cluster of differentiation

Table 4: Immunological classification of ALL [30].