Month/ Visit Baseline 1 2 3 4 5 6 7 8 9 10 11 12 Anamnesis X                         Demographic data X                         Physical examination X X* X* X* X X X X X X X X X Laboratory BCR-ABL qualitative White-cell count Platelet count Hemoglobin X                         X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Ph+ chromosome cytogenetic X                         BCR-ABL mutation (sequencing) X                         BCR-ABL quantitative (RQ-PCR) X                         Bone Marrow Puncture X                         Adverse events     X X X X X X X X X X X

Table 1: Visits and assessments.