| Article and Authors |
Number of Patients |
Skin Wounds |
PRP Treatment |
Time of Treatment |
| Sell et al. A case report on the use of sustained release platelet-rich plasma for the treatment of chronic pressure ulcers [29]. |
3 |
3 pressure ulcers |
autologous |
Patient 1:8 weeks
Patient 2:10 prp applications
Patient 3:5 prp applications |
| Yuan et al. The preliminary application of autologous platelet-rich gel used to treat refractory diabetic dermal ulcer. |
13 |
13 diabetic ulcers |
autologous |
69.2% cured in 3 weeks |
| Driver et al. A prospective, randomized, controlled trial of autologous platelet-rich plasma gel for the treatment of diabetic foot ulcers. |
72 divided into two groups: 40 for prp treatment, 32 in a control group |
40 diabetic ulcers |
autologous |
12 weeks |
| Sakata et al. A retrospective, longitudinal study to evaluate healing lower extremity wounds in patients with diabetes mellitus and ischemia using standard protocols of care and platelet-rich plasma gel in a Japanese wound care program. |
39 |
24 ischemic diabetic, 10 diabetic, 5 ischemic, 1 pressure ulcers |
autologous |
83% in 145.2 days |
| Cervelli et al. Application of enhanced stromal vascular fraction and fat grafting mixed with PRP in post-traumatic lower extremity ulcers. |
10 |
Post traumatic low extremity ulcers |
Fat grafting + prp |
97.8% in 9.7 weeks |
| Cervelliet al. Application of platelet-rich plasma in plastic surgery: clinical and in vitro evaluation. |
18 |
Chronic lower extremity ulcers |
Fat grafting + prp |
88.9% in 9.7 weeks |
| Kim et al. Application of platelet-rich plasma accelerates the wound healing process in acute and chronic ulcers through rapid migration and upregulation of cyclin A and CDK4 in HaCaT cells. |
16 |
11 chronic and 5 acute ulcers |
autologous |
9 of chronic ulcers healed in 15,18 days, the acute ones in 4-20 days |
| Sarvajnamurthyet al. Autologous platelet rich plasma in chronic venous ulcers: study of 17 cases. |
12 |
17 venous ulcers |
autologous |
5.1 weeks |
| Martinez-Zapata et al. Autologous platelet-rich plasma for treating chronic wounds. |
325 |
Chronic wounds |
autologous |
12 weeks ( 8 to 40) |
| Frykberget al. Chronic wounds treated with a physiologically relevant concentration of platelet-rich plasma gel: a prospective case series. |
49 |
65: the most common were 21 pressure, 16 venous and 14 diabetic ulcers. |
autologous |
97% improved in 2.8 weeks |
| De Angelis et al. Combined use of super-oxidised solution with negative pressure for the treatment of pressure ulcers: case report. |
1 |
1 pressure ulcer |
Intra- and per-lesionalprp injections |
Prpinfections were followed by surgery, after which wound reduction was observed |
| Scimecaet al. Novel use of platelet-rich plasma to augment curative diabetic foot surgery [13]. |
1 |
Diabetic ulcer |
autologous |
7 weeks |
| MasoudMehrannia et al. Platelet Rich Plasma for Treatment of Nonhealing Diabetic Foot Ulcers: A Case Report [30]. |
1 |
Diabetic ulcer |
autologous |
Treatment of 10 days, healed in 8 months |
| Knox et al. Platelet-rich plasma combined with skin substitute for chronic wound healing: a case report. |
1 |
Decubitus ulcer |
autologous |
6 weeks |
| SaadSetta et al. Platelet-rich plasma versus platelet-poor plasma in the management of chronic diabetic foot ulcers: a comparative study. |
12 |
Diabetic ulcers |
Prp treatment efficacy was compared to platelet-poor plasma (ppp) control group |
??? |
| Kim et al. Recalcitrant cutaneous ulcer of comorbid patient treated with platelet rich plasma: a case report. |
1 |
Traumatic cutaneous ulcer |
autologous |
7 applications of prp: healing in 3 months |
| Nishimoto et al. Supplementation of bone marrow aspirate-derived platelet-rich plasma for treating radiation-induced ulcer after cardiac fluoroscopic procedures: A preliminary report. |
4 |
Radiation induced ulcers |
Skin flap supplemented with autologous bone marrow prp |
??? |
| de Leon et al. The clinical relevance of treating chronic wounds with an enhanced near-physiological concentration of platelet-rich plasma gel. |
200 |
285 chronic wounds |
autologous |
96.5% of wounds had positive results in 2.2 weeks |
| Dionyssiou et al. The effectiveness of intralesional injection of platelet-rich plasma in accelerating the healing of chronic ulcers: an experimental and clinical. |
26 |
Chronic ulcers |
surgical debridement and intralesional injection of PRP |
10 healed in 7 weeks, 16 underwent on reconstructive procedure after woud bed preparation with prp |
| Cervelli et al. Tissue regeneration in loss of substance on the lower limbs through use of platelet-rich plasma, stem cells from adipose tissue, and hyaluronic acid. |
30 |
Various chronic wounds |
Autologous prp + fat grafts |
100% improvement in 3 weeks, 47% healing in 6 weeks, 57% healing in 3 months |
| Sano et al. Treatment of chronic ulcer with elastic plasma protein and platelet film for wound dressing. |
10 |
Chronic wounds |
Plasma proteins + autologous prp: platelet-protein film |
transcutaneous oxygen tension increased in 4 days, vascular density increased in 14 days. |
| Park et al. Treatment of refractory venous stasis ulcers with autologous platelet-rich plasma and light-emitting diodes: a pilot study. |
16 |
Venous ulcers |
Autologous prp + LED therapy |
75% improved in 6 weeks |
| Salazar-Álvarez et al. Use of Platelet-Rich Plasma in the Healing of Chronic Ulcers of the Lower Extremity. |
11 |
Non ischemic ulcers: venous and hypertensive ulcers |
autologous |
Improvement in 4 weeks |
