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Figure 2: Electron micrographs of negatively stained A. Recombinant pFVIII molecules. B. Lipid nanodiscs (ND) containing phosphatidylserine and C. Recombinant [FVIII molecules attached to the lipid ND in B. The full arrows show top and bottom views of the ND and rpFVIII-ND, respectively. The empty arrows show the side views of the ND and the dashed arrows show tilted views of the ND and rpFVIII-ND. The scale bar is 20 nm. The insets show magnified views of the rpFVIII, ND and rpFVIII-ND complexes. The scale bar is 10 nm. |