Biomarkers References
Cytokines Interleukin IL-10 [32,51]
  Immune activation markers soluble CD27*1 [53]
  Chemokine CXCL13*1 [52]
DNA Tumor-specific DNA methylation DAPK, p16, MGMT, p14, p73, etc*2 [63]
RNA miRNAs miR-17-92 cluster and miR21*1 [79]
*1These biomarkers were tested in the CSF of non-HIV-related PCNSL patients. *2 Tumor-specific methylated DNA in the CSF was not investigated. CSF, cerebrospinal fluid; IL-10, interleukin-10; miRNAs, microRNAs.
Table 2: Biomarker candidates in the CSF for diagnosing AIDS-related PCNSL