| |
AUCΔRVC(%•min) |
AUMCΔRVC (%•min2) |
MRTΔRVC(min) |
| Vehicle |
181.3 ± 7.9 |
7623.0 ± 321.5 |
42.0 ± 0.8 |
| CLZmicro |
904.1 ± 31.3*1 |
61593.7 ± 2286.4*1 |
68.1 ± 1.1*1 |
| CLZnano |
3909.4 ± 117.5*1,2 |
423018.2 ± 14105.3*1,2 |
108.2 ± 1.7*1,2 |
|
| Retinal vasoconstriction in the right eye was caused by intravitreal injection of ET-1. Parameters were calculated according to Eqs. 4-7 (see Materials and methods).Vehicle, vehicle-instilled rats; CLZmicro, CLZmicro-instilled rats; CLZnano, CLZnano-instilled rats. The data are presented as means ± S.E. of 6 independent rats. *1P< 0.05, vs. vehicle for each category. *2P<0.05, vs. CLZmicrofor each category. |
| Table 4: Pharmacokinetic parameters for thesuppression of retinal vasoconstriction by CLZnano in rats injected intra vitreally with ET-1 |
