Effect or Relationship L p-value of testing L=0 SES USES γalerting γcontrast γeffectsize γBESD A: Drug A 1• 0.18 0.019 0.32 0.78 0.173 0.320 0.155 0.047 B: Drug B 2• -0.18 0.019 -0.32 -0.78 -0.173 0.320 0.155 0.047 Average gender effect magnitude     0.32 0.78         C: Hour 4 •1 -1.38 0 -2.46 -4.26 -0.953 0.880 0.847 0.643 D: Hour 10 •2 0.48 3×10-5 0.85 1.47 0.330 0.539 0.293 0.093 E: Hour 16 •3 0.90 1×10-11 1.61 2.78 0.623 0.770 0.554 0.208 Average time effect magnitude     1.77 2.84         F: Linear 4.57 0 8.13 4.07 0.910 0.870 0.809 0.506 G: Quadratic 2.87 3×10-5 5.11 1.47 0.330 0.539 0.293 0.093

Table 7: Contrast analysis using traditional contrast L and effect sizes for an illustrative example on safety assessment of two drugs at three time points.