| Parameters used in the simulation study |
| Disease allele frequency P(A1) |
0.3, 0.5 |
| Single Marker allele frequency P(M1) |
0.3, 0.5 |
| Two-locus haplotype frequencies
(PM1N1,PM1N2,PM2N1,PM2N2) |
(0.3, 0.2, 0.1, 0.4) |
| GRR2
(=P(affected| A1A1)/ P(affected| A2A2)* |
0.15, 0.20 |
| Disease prevalence |
0.1 |
| Number of families simulated |
200, 500 |
| Number of iterations |
10,000 |
*GRR2: the homozygous genotypic risk ratio |
