| Threshold value, x | 
        No. studies with this    threshold | 
        Sensitivity | 
        Specificity | 
       
      
        | Summary estimate | 
        95% CI | 
        Summary estimate | 
        95% CI | 
         
      
        | lower   | 
         upper | 
        lower   | 
         upper | 
       
      
        | 0.13 | 
        1 | 
        0.941 | 
        0.896 | 
        0.967 | 
        0.698 | 
        0.544 | 
        0.818 | 
       
      
        | 0.14 | 
        2 | 
        0.936 | 
        0.889 | 
        0.963 | 
        0.720 | 
        0.572 | 
        0.832 | 
       
      
        | 0.15 | 
        5 | 
        0.930 | 
        0.882 | 
        0.959 | 
        0.740 | 
        0.597 | 
        0.845 | 
       
      
        | 0.16 | 
        3 | 
        0.924 | 
        0.875 | 
        0.955 | 
        0.756 | 
        0.618 | 
        0.856 | 
       
      
        | 0.17 | 
        3 | 
        0.919 | 
        0.867 | 
        0.951 | 
        0.770 | 
        0.637 | 
        0.865 | 
       
      
        | 0.18 | 
        3 | 
        0.913 | 
        0.859 | 
        0.948 | 
        0.782 | 
        0.653 | 
        0.873 | 
       
      
        | 0.19 | 
        4 | 
        0.907 | 
        0.851 | 
        0.944 | 
        0.793 | 
        0.666 | 
        0.880 | 
       
      
        | 0.2 | 
        6 | 
        0.902 | 
        0.843 | 
        0.940 | 
        0.801 | 
        0.678 | 
        0.885 | 
       
      
        | 0.21 | 
        3 | 
        0.896 | 
        0.835 | 
        0.937 | 
        0.809 | 
        0.688 | 
        0.890 | 
       
      
        | 0.22 | 
        1 | 
        0.891 | 
        0.827 | 
        0.933 | 
        0.815 | 
        0.697 | 
        0.894 | 
       
      
        | 0.23 | 
        1 | 
        0.886 | 
        0.820 | 
        0.930 | 
        0.820 | 
        0.704 | 
        0.897 | 
       
      
        | 0.24 | 
        2 | 
        0.881 | 
        0.812 | 
        0.926 | 
        0.824 | 
        0.709 | 
        0.900 | 
       
      
        | 0.25 | 
        2 | 
        0.876 | 
        0.805 | 
        0.923 | 
        0.828 | 
        0.714 | 
        0.902 | 
       
      
        | 0.28 | 
        2 | 
        0.862 | 
        0.786 | 
        0.914 | 
        0.834 | 
        0.724 | 
        0.907 | 
       
      
        | 0.3 | 
        4 | 
        0.854 | 
        0.774 | 
        0.909 | 
        0.837 | 
        0.727 | 
        0.908 | 
       
      
        | 0.31 | 
        1 | 
        0.850 | 
        0.768 | 
        0.906 | 
        0.838 | 
        0.729 | 
        0.909 | 
       
      
        | 0.32 | 
        1 | 
        0.846 | 
        0.763 | 
        0.904 | 
        0.839 | 
        0.730 | 
        0.909 | 
       
      
        | 0.35 | 
        1 | 
        0.835 | 
        0.748 | 
        0.897 | 
        0.841 | 
        0.733 | 
        0.910 | 
       
      
        | 0.39 | 
        2 | 
        0.822 | 
        0.729 | 
        0.888 | 
        0.846 | 
        0.740 | 
        0.914 | 
       
      
        | 0.4 | 
        2 | 
        0.819 | 
        0.724 | 
        0.886 | 
        0.848 | 
        0.743 | 
        0.915 | 
       
      
        | 0.45 | 
        1 | 
        0.800 | 
        0.699 | 
        0.874 | 
        0.867 | 
        0.770 | 
        0.927 | 
       
      
        | 0.49 | 
        1 | 
        0.781 | 
        0.674 | 
        0.860 | 
        0.892 | 
        0.806 | 
        0.943 | 
       
      
        | 0.5 | 
        2 | 
        0.775 | 
        0.665 | 
        0.857 | 
        0.900 | 
        0.816 | 
        0.948 | 
       
      |