Table 3

Risk/protective variants	Number of variants	Relative risk	MAF-Cutoff	*NET*	*SKAT*	*REP*	*C-ALPHA*	MB	*CMC*
15/0	100	3.0	0.01	90.7	58.7	54.7	58.9	45.7	48.0
10/0	100	3.0	0.01	74.3	38.6	34.1	38.0	28.6	30.2
15/10	100	3.0	0.01	91.9	58.8	51.1	57.6	37.7	40.4
10/10	100	3.0	0.01	76.9	41.3	27.2	41.9	19.2	22.3
15/0	100	2.0	0.01	54.0	20.0	23.0	18.7	16.6	15.8
10/0	100	2.0	0.01	38.8	15.1	18.8	14.2	12.1	12.6
15/10	100	2.0	0.01	51.4	19.9	20.2	18.9	13.3	14.3
10/10	100	2.0	0.01	38.9	14.4	12.9	13.4	10.2	10.7
15/0	500	3.0	0.01	75.7	30.8	18.9	31.6	12.5	11.5
10/0	500	3.0	0.01	55.6	21.5	14.1	21.5	9.3	7.0
15/10	500	3.0	0.01	73.7	35.9	17.4	36.9	10.9	10.1
10/10	500	3.0	0.01	54.6	19.7	10.5	20.0	8.0	7.5
15/0	500	2.0	0.01	31.7	10.8	10.6	9.2	7.7	5.6
10/0	500	2.0	0.01	21.8	9.2	8.8	7.3	6.6	4.2
15/10	500	2.0	0.01	34.8	12.2	9.0	11.7	7.1	6.4
10/10	500	2.0	0.01	22.0	8.8	7.1	8.6	5.5	5.6
15/0	100	3.0	0.05	99.9	97.2	96.6	98.8	92.0	90.1
10/0	100	3.0	0.05	99.0	86.9	80.3	96.3	70.2	78.7
15/10	100	3.0	0.05	100,00	98.5	94.7	99.5	88.4	89.5
10/10	100	3.0	0.05	99.5	87.3	74.3	96.9	61.0	75.4
15/0	100	2.0	0.05	95.9	59.8	66.7	75.0	53.9	51.9
10/0	100	2.0	0.05	84.5	41.4	40.0	58.8	27.8	35.7
15/10	100	2.0	0.05	94.9	60.0	58.3	71.2	45.7	49.2
10/10	100	2.0	0.05	85.9	40.7	34.0	57.0	25.0	33.4
15/0	500	3.0	0.05	99.7	83.5	60.8	97.9	35.5	21.9
10/0	500	3.0	0.05	98.9	63.5	40.2	93.5	19.9	17.0
15/10	500	3.0	0.05	99.9	85.1	60.3	98.1	33.6	22.5
10/10	500	3.0	0.05	98.6	62.7	34.3	92.7	17.1	14.5
15/0	500	2.0	0.05	95.1	36.3	24.2	65.4	13.3	10.7
10/0	500	2.0	0.05	80.2	20.0	16.2	43.1	9.7	6.00
15/10	500	2.0	0.05	92.3	35.9	23.6	63.3	14.2	8.5
10/10	500	2.0	0.05	81.2	20.8	13.5	45.4	8.3	7.1

Note: All shown power estimates are based on 1000 replicates and 1000 permutations.

Table 3: Power estimates of the outlined approaches for the skewed scenario (100/500 variants, upper MAF-threshold 0.01/0.05, 500/500 cases/controls).