Example of few patient profile   Patients information Risk estimation of difference method for each patients Percentage change from SM Age group (<55=0 ; ≥ 55=1) Gender (female=0 ; male=1) Duration of DM (< 5 = 0 ; ≥ 5=1) History of family diabetes (no=0 ; yes=1) User of insulin (no=0 ; yes=1) History of hypertension (no=0 ; yes=1) BMI (non obese = 0;obese=1) Physical activity (heavy =0; moderate and less=1) FBS value (< 130=0; ≥ 130 =1) HbA1c (≤7-0=0; >7 =1) Anemia (no=0 ; yes=1) Nephropathy (no=0 ; yes=1) SM M1 M2 M3 M4 M5 M1 M2 M3 M4 M5 Patient 1 0 0 0 0 1 0 0 0 1 1 0 1 18.8 20.1 16.4 16.7 18.8 18.9 6.9 -12.6 -11.1 0.3 0.4 Patient 2 1 0 0 1 0 0 0 0 1 1 0 0 4.6 4.8 4.1 4.2 4.6 4.6 5.8 -9.9 -8.9 0.6 1.9 Patient 3 0 1 0 0 1 1 0 0 1 0 0 1 34.1 35.9 32.9 33.4 34.3 34.0 5.3 -3.5 -1.8 0.8 0.0 Patient 4 1 1 0 1 1 0 0 0 0 1 0 0 19.5 20.1 18.6 16.7 19.6 19.6 3.0 -4.6 -14.4 0.6 0.7 Patient 5 1 1 0 0 1 1 0 0 0 1 0 1 41.7 43.0 39.9 40.6 42.0 41.9 3.1 -4.4 -2.8 0.6 0.3 Patient 6 0 1 1 0 1 1 0 0 1 0 0 1 64.3 65.0 62.3 63.1 64.6 64.2 1.1 -3.0 -1.8 0.4 -0.1 Patient 7 0 1 1 1 0 1 0 0 0 0 1 0 16.1 15.7 16.4 16.7 16.1 16.0 -2.6 1.9 3.7 0.2 -0.7 Patient 8 1 1 1 1 1 1 1 1 1 1 1 1 87.9 88.3 84.8 88.8 88.1 88.1 0.5 -3.4 1.0 0.2 0.2 Patient 9 0 0 1 0 1 1 0 0 0 0 1 1 40.5 40.6 39.9 40.6 40.5 40.2 0.2 -1.4 0.2 -0.1 -0.6 Patient 10 0 0 1 1 1 1 0 0 1 1 0 1 77.6 78.9 75.3 75.9 77.7 77.7 1.7 -3.0 -2.2 0.1 0.2 Patient 11 0 1 1 1 1 1 0 0 1 1 0 0 73.9 75.4 72.3 69.9 74.1 74.1 2.0 -2.2 -5.4 0.2 0.2 Patient 12 0 0 1 1 0 1 0 0 1 1 0 1 39.7 40.6 36.3 40.6 39.9 39.8 2.3 -8.5 2.2 0.4 0.4 DM- Diabetes Mellitus; BMI- Body Mass Index; FBS- Fasting Blood Sugar; Hba1c- Glycated Hemoglobin

Table 4: The validating different methods of risk estimation and identifying percentage change from SM using SN–DREAMS III data.