| |
Definition |
What does this mean clinically? |
Alpha - α
(Type I Error probability)
Significance Level of a test |
Probability of rejecting the null hypothesis when it is true |
Superiority Setting - Falsely claiming a difference
Non-inferiority Setting - Falsely claiming a similarity |
Beta – β
(Type II Error probability) Complementary to power of a test |
Probability of failing to reject a false null hypothesis |
Superiority Setting - Falsely claiming no difference
Non-inferiority Setting - Falsely claiming a difference |
| Delta - δ (Minimum Clinically Relevant Difference or CRD) |
What is the minimum treatment effect that would ultimately change clinical practice? |
Superiority – lower bound on efficacy advantage of treatment
Non-inferiority – upper bound on efficacy disadvantage of treatment |
