| Effect | Separate model (PR&RR) | Joint model (PR&RR) | |||||||
| Estimate (SE) | P-value | (1-α)100% CI | Estimate (SE) | P-value | (1-α)100% CI | ||||
| For PR | |||||||||
| Inter(β10) | 107.04(4.415) | <.0001 | (98.37,115.71) | 108.58(4.384) | <.0001 | (99.97,117.1) | |||
| Time(β11) | -3.15(0.123) | <.0001 | (-3.39,-2.904) | -3.16(0.122) | <.0001 | (-3.4,-2.923) | |||
| Age(β12) | -0.41(0.053) | <.0001 | (-0.513,-0.304) | -0.43(0.053) | <.0001 | (-0.53,-0.32) | |||
| Sex(β13) | 4.804(1.422) | 0.0008 | (2.007,7.602) | 4.528(1.335) | 0.0008 | (1.902,7.153) | |||
NYHA Class |
II(β14) | 2.743(1.913) | 0.1528 | (-1.024,6.51) | 3.187(1.908) | 0.0961 | (-0.57,6.944) | ||
| III(β15) | 5.167(2.423) | 0.0339 | (0.396,9.938) | 5.896(2.415) | 0.0153 | (1.14,10.652) | |||
| IV(β16) | 15.153(2.801) | <.0001 | (9.637,20.669) | 16.055(2.794) | <.0001 | (10.55,21.56) | |||
| L(β17) | -0.31(0.016) | <.0001 | (-0.339,-0.275) | -0.30(0.016) | <.0001 | (-0.33,-0.26) | |||
| T*L(β18) | 0.009(0.0008) | <.0001 | (0.0075,0.011) | 0.009(0.0008) | <.0001 | (0.007,0.01) | |||
| W(β19) | 0.538(0.033) | <.0001 | (0.474,0.603) | 0.521(0.032) | <.0001 | (0.458,0.584) | |||
| T*W(β110) | 0.016(0.0014) | <.0001 | (0.013, 0.019) | 0.016(0.0014) | <.0001 | (0.013,0.019) | |||
| Sigma1(σ1) | 31.53(0.58) | <.0001 | (30.423,32.699) | 31.579(0.582) | <.0001 | (30.47,32.751) | |||
 |
141.27(13.14) | <.0001 | (118.68,171.03) | 140.62(13.16) | <.0001 | (118.02,170.44) | |||
 |
-2.207(0.395) | <.0001 | (-2.982,-1.432) | -2.078(0.388) | <.0001 | -2.84(-1.317) | |||
 |
0.182(0.02) | <.0001 | (0.148,0.229) | 0.176(0.019) | <.0001 | (0.143,0.221) | |||
| For RR | |||||||||
Inter( ) |
37.08(1.785) | <.0001 | (33.57,40.59) | 36.57(1.78) | <.0001 | (33.06,40.07) | |||
Time( ) |
-0.787(0.034) | <.0001 | (-0.853,-0.72) | -0.779(0.034) | <.0001 | (-0.845,-0.713) | |||
Age( ) |
-0.258(0.025) | <.0001 | (-0.308,-0.209) | -0.256(0.025) | <.0001 | (-0.305,-0.207) | |||
Sex( ) |
1.605(0.578) | 0.0057 | (0.47,2.739) | 1.734(0.569) | 0.0024 | (0.617,2.851) | |||
| NYHA | II( ) |
2.056 (0.898) | 0.0227 | (0.289,3.823) | 1.99(0.895) | 0.0270 | (0.228,3.753) | ||
| III(β25) | 4.022 (1.136) | 0.0005 | (1.786,6.258) | 3.936(1.133) | 0.0006 | (1.706,6.166) | |||
| IV(β26) | 8.937(1.314) | <.0001 | (6.349,11.525) | 8.83(1.311) | <.0001 | (6.249,11.412) | |||
| L(β27) | -0.075(0.004) | <.0001 | (-0.082,-0.067) | -0.075(0.004) | <.0001 | (-0.082,-0.067) | |||
| T*L(β28) | 0.002(0.0002) | <.0001 | (0.0019,0.0026) | 0.002(0.00019) | <.0001 | (0.002,0.0026) | |||
| W (β29) | 0.054 (0.0081) | <.0001 | (0.038,0.07) | 0.059 (0.008) | <.0001 | (0.043,0.075) | |||
| T*W(β210) | 0.003 (0.0004) | <.0001 | (0.002,0.0034) | 0.003(0.00035) | <.0001 | (0.002,0.0033) | |||
| Sigma2σ2 | 1.654 (0.031) | <.0001 | (1.595,1.715) | 1.657(0.031) | <.0001 | (1.598,1.719) | |||
 |
31.63 (2.915) | <.0001 | (26.61,38.22) | 31.696 (2.93) | <.0001 | (26.658,38.319) | |||
 |
-0.604(0.112) | <.0001 | (-0.82,-0.39) | -0.6 (0.11) | <.0001 | (-0.82,-0.38) | |||
 |
0.066 (0.007) | <.0001 | (0.054,0.083) | 0.064(0.0068) | <.0001 | (0.052,0.079) | |||
| Common parameters |  |
- | 32.626(4.763) | <.0001 | (23.292,41.96) | ||||
 |
0.23(0.22) | 0.2939 | (-0.2,0.66) | ||||||
 |
-0.037(0.172) | 0.8283 | (-0.375,0.3) | ||||||
 |
0.075(0.004) | <.0001 | (0.012, 0.138) | ||||||
| Rho (ρ) | 0.7054(0.032) | <.0001 | (0.642,0.769) | ||||||
