| Method |
Arm |
Response rate |
Sample size |
# of patient assigned (SD) |
Pr(selected) |
degree of imbalance |
Percentage of significantly imbalanced covariate |
| Scenario1: p1=p2=p3=0.1 |
EQ
(τ1=τ2=0) |
A |
0.1 |
60.12 |
19.85 (13.69) |
0.056 |
0.35 |
0.11 |
| B |
0.1 |
20.11 (13.71) |
0.061 |
| C |
0.1 |
20.15 (13.69) |
0.057 |
RA
(τ1=1,τ2=0) |
A |
0.1 |
58.06 |
19.30 (14.18) |
0.061 |
0.33 |
0.097 |
| B |
0.1 |
19.67 (14.19) |
0.063 |
| C |
0.1 |
19.09 (13.98) |
0.06 |
CA
(τ1=0,τ2=1) |
A |
0.1 |
61.01 |
20.89 (13.69) |
0.06 |
0.29 |
0.018 |
| B |
0.1 |
20.11 (13.58) |
0.061 |
| C |
0.1 |
20.59 (13.65) |
0.063 |
| RACA1 |
A |
0.1 |
57.01 |
18.45 (14.13) |
0.064 |
0.34 |
0.079 |
| B |
0.1 |
19.38 (14.03) |
0.068 |
| C |
0.1 |
19.16 (14.17) |
0.062 |
RACA2
(τ1=τ2=1) |
A |
0.1 |
57.39 |
19.00 (13.95) |
0.051 |
0.32 |
0.038 |
| B |
0.1 |
19.18 (14.01) |
0.052 |
| C |
0.1 |
19.21 (14.07) |
0.056 |
RACA3
(τ1=1,τ2=2) |
A |
0.1 |
60.13 |
20.62 (14.06) |
0.052 |
0.3 |
0.032 |
| B |
0.1 |
19.90 (14.03) |
0.057 |
| C |
0.1 |
19.60 (14.06) |
0.048 |
| Scenario 2: p1=0.1,p2=0.2,p3=0.3 |
EQ
(τ1=τ2=0) |
A |
0.1 |
68.48 |
19.89 (13.33) |
0.056 |
0.32 |
0.154 |
| B |
0.2 |
25.44 (12.69) |
0.538 |
| C |
0.3 |
23.16 (12.10) |
0.881 |
RA
(τ1=1,τ2=0) |
A |
0.1 |
63.71 |
17.16 (14.03) |
0.056 |
0.32 |
0.153 |
| B |
0.2 |
23.33 (13.93) |
0.439 |
| C |
0.3 |
23.22 (11.97) |
0.818 |
CA
(τ1=0,τ2=1) |
A |
0.1 |
70.51 |
20.28 (13.33) |
0.057 |
0.25 |
0.018 |
| B |
0.2 |
26.41 (12.13) |
0.521 |
| C |
0.3 |
23.81 (11.93) |
0.913 |
| RACA1 |
A |
0.1 |
65.97 |
17.98 (14.12) |
0.044 |
0.3 |
0.071 |
| B |
0.2 |
24.56 (13.30) |
0.511 |
| C |
0.3 |
23.43 (12.02) |
0.855 |
RACA2
(τ1=τ2=1) |
A |
0.1 |
67.67 |
17.94 (14.11) |
0.048 |
0.27 |
0.041 |
| B |
0.2 |
24.92 (13.24) |
0.525 |
| C |
0.3 |
24.81 (11.66) |
0.878 |
RACA3
(τ1=1,τ2=2) |
A |
0.1 |
68.49 |
18.89 (14.13) |
0.052 |
0.26 |
0.038 |
| B |
0.2 |
25.10 (13.03) |
0.533 |
| C |
0.3 |
24.50 (11.78) |
0.886 |
|
