Cross-flow microfiltration (i.e. plate-frame, hollow-fiber) |
Clarification recovery of 90% can be achieved and the operation is scalable. |
Protein recovery is dependent on the protein biochemical properties. |
Static dead-end filtration |
Clarification recovery of ≥ 90% can be achieved by using a series of depth and absolute filters. |
The operation is difficult at a larger scale (i.e. 200 L) and there will be more expensive capital (housings, pipings, filters) and operational costs to be considered. |
Batch Clarification using ion-exchange resins |
Clarification recovery of ≥ 90% can be achieved. The operation is the cheapest at the large-scale in comparison to micro or static filtration |
Automation of this method may aid in reducing the amount of manual manipulations at the larger scale. |
