Response variable Source DF SS MS F-value p-value Theobromine accumulateda Model 9 1027000 114100 21.23 0.0001 Error Lack of fit Pure error 8 42973.56 5371.69     5 42789.67 8557.93 139.62 0.0009 3 183.89 61.3     Total 19 1073000                   Molar yieldb Model 9 8086.74 898.53 14.74 0.0004 Error Lack of fit Pure error 8 487.52 60.94     5 479.01 95.80 33.76 0.0077 3 8.51 2.84     Total 19 8852.86

aR2 = 0.9598; adjusted R2= 0.9146 bR2 = 0.9431; adjusted R2= 0.8792

Table 3: ANOVA for the quadratic models predicted for each response variable.