| DPO |
Cut-off titer
MAT |
AND/OR |
Cut-off
titer
IgM ELISA |
Sensitivity (%) |
95% CI |
Specificity (%) |
95% CI |
| 1-10 |
≥1:80 |
AND |
≥1:40 |
10.4 |
5.8-18.1 |
100.0 |
94.2-100.0 |
| ≥1:80 |
OR |
≥1:40 |
33.3 |
24.7-43.2 |
90.3 |
80.4-95.5 |
| ≥1:80 |
AND |
≥1:80 |
10.4 |
5.8-18.1 |
100.0 |
94.2-100.0 |
| ≥1:80 |
OR |
≥1:80 |
27.1 |
19.2-36.7 |
93.5 |
84.6-97.5 |
| ≥1:160 |
AND |
≥1:40 |
6.3 |
2.9-13.0 |
100.0 |
94.2-100.0 |
| ≥1:160 |
OR |
≥1:40 |
31.3 |
22.9-41.1 |
96.8 |
89.0-99.1 |
| ≥1:160 |
AND |
≥1:80 |
6.3 |
2.9-13.0 |
100.0 |
94.2-100.0 |
| ≥1:160 |
OR |
≥1:80 |
25.0 |
17.4-34.5 |
100.0 |
94.2-100.0 |
| 11-20 |
≥1:80 |
AND |
≥1:40 |
90.0 |
79.9-95.3 |
98.4 |
91.5-99.7 |
| ≥1:80 |
OR |
≥1:40 |
96.7 |
88.6-99.1 |
85.7 |
75.0-92.3 |
| ≥1:80 |
AND |
≥1:80 |
86.7 |
75.8-93.1 |
100.0 |
94.2-100.0 |
| ≥1:80 |
OR |
≥1:80 |
95.0 |
86.3-98.3 |
90.5 |
80.7-95.6 |
| ≥1:160 |
AND |
≥1:40 |
81.7 |
70.1-89.4 |
100.0 |
94.2-100.0 |
| ≥1:160 |
OR |
≥1:40 |
96.7 |
88.6-99.1 |
93.7 |
84.8-97.5 |
| ≥1:160 |
AND |
≥1:80 |
80.0 |
68.2-88.2 |
100.0 |
94.2-100.0 |
| ≥1:160 |
OR |
≥1:80 |
93.3 |
84.1-97.4 |
100.0 |
94.2-100.0 |
| >20 |
≥1:80 |
AND |
≥1:40 |
81.5 |
70.4-89.1 |
98.4 |
91.5-99.7 |
| ≥1:80 |
OR |
≥1:40 |
95.4 |
87.3-98.4 |
85.7 |
75.0-92.3 |
| ≥1:80 |
AND |
≥1:80 |
67.7 |
55.6-77.8 |
100.0 |
94.2-100.0 |
| ≥1:80 |
OR |
≥1:80 |
90.8 |
81.3-95.7 |
90.5 |
80.7-95.6 |
| ≥1:160 |
AND |
≥1:40 |
76.9 |
65.4-85.5 |
100.0 |
94.2-100.0 |
| ≥1:160 |
OR |
≥1:40 |
93.8 |
85.2-97.6 |
93.7 |
84.8-97.5 |
| ≥1:160 |
AND |
≥1:80 |
63.1 |
50.9-73.8 |
100.0 |
94.2-100.0 |
| ≥1:160 |
OR |
≥1:80 |
89.2 |
79.4-94.7 |
100.0 |
94.2-100.0 |
Bold text indicates the optimal cut-off for sensitivity and specificity combinations with priority on a high specificity. |
