Figure 2: The immune response during infection with S. mansoni . The early response to egg antigens is of the Th-1 type, characterized by the indicated signature T cell and APC-derived cytokines; this response switches to a Th-2 type, also marked by typical cytokines. The upper box lists factors that facilitate the Th-1 to Th-2 switch. In contrast, conditions listed in the lower box oppose the Th-1 to Th-2 switch. [Modified from 20].